Natural phenolic compounds protect LDL against oxidation

Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans.

Olive oil phenolic compounds are potent antioxidants in vitro, but evidence for antioxidant action in vivo is controversial. We examined the role of the phenolic compounds from olive oil on postprandial oxidative stress and LDL antioxidant content. Oral fat loads of 40 mL of similar olive oils, but with high (366 mg/kg), moderate (164 mg/kg), and low (2.7 mg/kg) phenolic content, were administe...

Commercial Laccase Oxidation of Phenolic Compounds

Lacazele sunt enzime aparţinând clasei oxidazelor, ce conţin în centrul catalitic patru atomi de cupru. Aceștia transferă electroni de la substratul ce se oxidează la cofactorul oxigen, acesta din urmă transformându-se în apă. Compușii fenolici sunt cei mai potriviţi ca substrat pentru acest tip de enzime. Lucrarea prezintă rezultatele obţinute la oxidarea următorilor compuşi: 1,2-dixidroxibenz...

Phenolic Compounds Protect Cultured Hippocampal Neurons against Ethanol-Withdrawal Induced Oxidative Stress

Ethanol withdrawal is linked to elevated oxidative damage to neurons. Here we report our findings on the contribution of phenolic antioxidants (17beta-estradiol, p-octyl-phenol and 2,6-di-tert-butyl-4-methylphenol) to counterbalance sudden ethanol withdrawal-initiated oxidative events in hippocampus-derived cultured HT-22 cells. We showed that ethanol withdrawal for 4 h after 24-h ethanol treat...

The Use of Pomegranate (Punica granatum L.) Phenolic Compounds as Potential Natural Prevention Against IBDs

Purified human serum PON1 does not protect LDL against oxidation in the in vitro assays initiated with copper or AAPH.

Purified serum paraoxonase (PON1) had been shown to attenuate the oxidation of LDL in vitro. We critically reevaluated the antioxidant properties of serum PON1 in the in vitro assays initiated with copper or the free radical generator 2,2'-azobis-2-amidinopropane hydrochloride (AAPH). The antioxidant activity of different purified PON1 preparations did not correlate with their arylesterase (AE)...